Allegro Ophthalmics announced the expansion of the company’s anti-integrin portfolio with the new topical dry eye disease drug candidate ALG-1007. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate), currently being developed for diabetic macular edema (DME) and intermediate dry age-related
ALG-1007, a topical drop, is the company’s second exploratory integrin-regulating drug candidate. In May, Allegro announced that the ex-U.S. proof-of-concept clinical trial concluded that ALG- 1007 was well-tolerated and demonstrated a dose-response with improvement of the signs and symptoms of DED as early as 2 weeks.
proof-of-concept clinical trial for the treatment of dry eye disease (DED) will be presented during the 37 th Congress of the Allegro’s other ophthalmology assets include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease, which is currently in phase 2 development outside the United States. ALG-1007 is a topical integrin regulator in development for potential use in patients with dry eye disease. ALG-1007 demonstrated a strong signal in an ex-U.S. proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated.
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Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in DED. ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study.
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Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in Phase 2 development outside the United States. The Option payment totaling $50 million would be made in two tranches, with the first payment of $10 million upon signing.
Phase 2 study. For more information, visit www.allegroeye.com. ALG-1007 (Allegro Ophthalmics, San Juan Capistrano, CA, USA) is a topical application of risuteganib, a small peptide integrin regulator that modulates multiple integrin subunits, including integrin αM and β2, the subunits involved in complement 3 inflammatory pathways. [ 11, 12] Gene expression studies have demonstrated reduced gene level of integrin αM and β2 submits in mice retina treated with risuteganib. ALG 1007, a peptide integrin inhibitor is being developed by Allegro Ophthalmics for the treatment of dry eye disease (DED). ALG 1007 inhibits the leucocyte
Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. The views and opinions expressed herein are the views
ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ®), currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration (intermediate dry AMD).
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ALG-1007. 05.14.19. Allegro Announces Positive Results of Ex-US Proof-of-Concept Trial With ALG-1007 for Dry Eye Disease.
proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S.
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Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in DED. ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study.
The Option payment totaling $50 million would be made in two tranches, with the first payment of $10 million upon signing.